Arvita Therapuetics
Arvita is a therapeutics company developing transformative therapies enhancing quality of life for those with NF1
Our current area of focus:
Cancer Vaccine Technology
At Arvita Therapeutics, we are leveraging the power of mRNA therapeutics to develop novel vaccines targeting tumors commonly found in individuals with Neurofibromatosis Type 1 (NF1). Our approach focuses on identifying and targeting shared tumor antigens, paving the way for potential therapeutic options for a broader population of NF1 patients. We are also interested in mRNA therapeutics that target expression changes associated with the disease.
Tumor Antigen & Target Discovery
Cancer cells express unique proteins on their surface called tumor-specific antigens (TSAs) or neoantigens. These antigens are different from those found on healthy cells and can act as flags, allowing the immune system to recognize and target cancer cells.
Our research leverages genome sequencing, proteomics and bioinformatics to identify both shared tumor antigens common across NF1 patients.
By pinpointing these common targets, we aim to develop a vaccine with broad applicability across NF1 patients while also developing personalized approaches for each patient.
mRNA Vaccine Design & Optimization
Once identified, these shared tumor antigens become the blueprints for our mRNA vaccine. We use Artificial Intelligence to design and synthesize mRNA sequences encoding these antigens, optimizing them for efficient delivery, safety and robust immune response.
Preclinical Validation & Clinical Development
We utilize preclinical models that closely mimic NF1-associated tumors to assess the vaccine's ability to trigger a targeted immune response and control tumor growth. Promising preclinical data will pave the way for Investigational New Drug (IND) application and subsequent clinical trials to evaluate the safety and efficacy of the vaccine in humans with NF1.
Join the Team
At Arvita Therapeutics, we're on a mission to make a meaningful impact in the fight against NF1 and childhood tumors. We believe in the power of science and innovation to transform lives.
We're looking for passionate, driven individuals to join our team as we pioneer new therapies and push the boundaries of what's possible in biotech.
If you're ready to be part of a dynamic, purpose-driven organization where your work will directly contribute to improving children's health, we want to hear from you.
